Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications

Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications

Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohist...

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Bibliographic Details
Main Authors: Francesca Addante, Antonio d’Amati, Angela Santoro, Giuseppe Angelico, Frediano Inzani, Damiano Arciuolo, Antonio Travaglino, Antonio Raffone, Nicoletta D’Alessandris, Giulia Scaglione, Michele Valente, Giordana Tinnirello, Stefania Sfregola, Belen Padial Urtueta, Alessia Piermattei, Federica Cianfrini, Antonino Mulè, Emma Bragantini, Gian Franco Zannoni
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
MSI
MMR deficiency
endometrial cancer
histomolecular prognostic risk assessment
immunotherapy
Online Access:https://www.mdpi.com/1422-0067/25/2/1056

Internet

https://www.mdpi.com/1422-0067/25/2/1056

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