Tregs with an MHC class II peptide–specific chimeric antigen receptor prevent autoimmune diabetes in mice

Tregs with an MHC class II peptide–specific chimeric antigen receptor prevent autoimmune diabetes in mice

Adoptive immunotherapy with Tregs is a promising approach for preventing or treating type 1 diabetes. Islet antigen–specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical application. To generate Tregs that recognize islet antigen...

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Bibliographic Details
Main Authors: Justin A. Spanier, Vivian Fung, Christine M. Wardell, Mohannad H. Alkhatib, Yixin Chen, Linnea A. Swanson, Alexander J. Dwyer, Matthew E. Weno, Nubia Silva, Jason S. Mitchell, Paul C. Orban, Majid Mojibian, C. Bruce Verchere, Brian T. Fife, Megan K. Levings
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-09-01
Series:The Journal of Clinical Investigation
Subjects:
Autoimmunity
Immunology
Online Access:https://doi.org/10.1172/JCI168601

Internet

https://doi.org/10.1172/JCI168601

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