Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site.
The human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein, gp120, possesses conserved binding sites for interaction with the primary virus receptor, CD4, and also for the co-receptor, generally CCR5. Although gp120 is a major target for virus-specific neutralizing antibodies, th...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-05-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2680979?pdf=render |