Transcriptome Analysis Reveals Altered Inflammatory Pathway in an Inducible Glial Cell Model of Myotonic Dystrophy Type 1

Transcriptome Analysis Reveals Altered Inflammatory Pathway in an Inducible Glial Cell Model of Myotonic Dystrophy Type 1

Myotonic dystrophy type 1 (DM1), the most frequent inherited muscular dystrophy in adults, is caused by the CTG repeat expansion in the 3′UTR of the <i>DMPK</i> gene. Mutant <i>DMPK</i> RNA accumulates in nuclear foci altering diverse cellular functions including alternative...

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Bibliographic Details
Main Authors: Cuauhtli N. Azotla-Vilchis, Daniel Sanchez-Celis, Luis E. Agonizantes-Juárez, Rocío Suárez-Sánchez, J. Manuel Hernández-Hernández, Jorge Peña, Karla Vázquez-Santillán, Norberto Leyva-García, Arturo Ortega, Vilma Maldonado, Claudia Rangel, Jonathan J. Magaña, Bulmaro Cisneros, Oscar Hernández-Hernández
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomolecules
Subjects:
myotonic dystrophy type 1
inducible cell models
RNA foci
gene expression
microarrays
Online Access:https://www.mdpi.com/2218-273X/11/2/159

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https://www.mdpi.com/2218-273X/11/2/159

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