FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).

FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).

Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease with no effective treatment. The genetic cause of FSHD is complex and the primary pathogenic insult underlying the muscle disease is unknown. Several disease candidate genes have been proposed including DUX4 and FRG1. Exp...

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Bibliographic Details
Main Authors: Sandra J Feeney, Meagan J McGrath, Absorn Sriratana, Stefan M Gehrig, Gordon S Lynch, Colleen E D'Arcy, John T Price, Catriona A McLean, Rossella Tupler, Christina A Mitchell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0117665

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https://doi.org/10.1371/journal.pone.0117665

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