PD-1 knockout on cytotoxic primary murine CD8+ T cells improves their motility in retrovirus infected mice

PD-1 knockout on cytotoxic primary murine CD8+ T cells improves their motility in retrovirus infected mice

Cytotoxic T lymphocyte (CTL) motility is an important feature of effective CTL responses and is impaired when CTLs become exhausted, e.g. during chronic retroviral infections. A prominent T cell exhaustion marker is programmed cell death protein 1 (PD-1) and antibodies against the interaction of PD-...

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Bibliographic Details
Main Authors: Daniela Mittermüller, Lucas Otto, Annika Loredana Kilian, Ann-Kathrin Schnormeier, Elisabeth Littwitz-Salomon, Anja Hasenberg, Ulf Dittmer, Matthias Gunzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
cytotoxic T lymphocytes
cell motility
anti-viral response
retrovirus
CRISPR/Cas9
PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1338218/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1338218/full

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