Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival

Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival

Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/Cas9, incorporating orthologs of the human oncogeni...

Full description

Bibliographic Details
Main Authors: Kathrin Pfeifer, Georg Wolfstetter, Vimala Anthonydhason, Tafheem Masudi, Badrul Arefin, Mats Bemark, Patricia Mendoza-Garcia, Ruth H. Palmer
Format: Article
Language:English
Published: The Company of Biologists 2022-08-01
Series:Disease Models & Mechanisms
Subjects:
neuroblast
tumor
brain
visceral mesoderm
signaling
rtk
neurogenesis
neuroblastoma
Online Access:http://dmm.biologists.org/content/15/8/dmm049591

Internet

http://dmm.biologists.org/content/15/8/dmm049591

Similar Items