Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound

Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound

We describe the multigram synthesis and in vivo efficacy studies of a donepezil‒huprine hybrid that has been found to display a promising in vitro multitarget profile of interest for the treatment of Alzheimer’s disease (AD). Its synthesis features as the key step a novel multigram preparative chro...

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Bibliographic Details
Main Authors: Irene Sola, Elisabet Viayna, Tània Gómez, Carles Galdeano, Matteo Cassina, Pelayo Camps, Margherita Romeo, Luisa Diomede, Mario Salmona, Pilar Franco, Mireille Schaeffer, Diego Colantuono, David Robin, Daniela Brunner, Nicole Taub, Birgit Hutter-Paier, Diego Muñoz-Torrero
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Molecules
Subjects:
disease-modifying anti-Alzheimer drugs
multitarget drugs
neuroprotection
animal models of Alzheimer’s disease
multigram preparative chromatographic resolution
Online Access:http://www.mdpi.com/1420-3049/20/3/4492

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http://www.mdpi.com/1420-3049/20/3/4492

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