Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models

Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models

Background The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline. The A3 adenosine receptor (A3AR) is the only adenosine subtype overexpressed in inflammatory...

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Bibliographic Details
Main Authors: Yumi Kim, So Young Kwon, Hong Soo Jung, Yoo Jung Park, Yong Shin Kim, Jang Hyeok In, Jin Woo Choi, Jin A Kim, Jin Deok Joo
Format: Article
Language:English
Published: Korean Society of Anesthesiologists 2019-02-01
Series:Korean Journal of Anesthesiology
Subjects:
adenosine a3
amitriptyline
cyclic amp response element-binding protein
cytokine
mitogen-activated protein kinase
Online Access:http://ekja.org/upload/pdf/kja-d-18-00022.pdf

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http://ekja.org/upload/pdf/kja-d-18-00022.pdf

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