MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling

MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling

Abstract Background Microglial polarization is a dynamic response to acute brain hypoxia induced by stroke and traumatic brain injury (TBI). However, studies on the polarization of microglia in chronic cerebral circulation insufficiency (CCCI) are limited. Our objective was to investigate the effect...

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Bibliographic Details
Main Authors: Meng Mao, Yi Xu, Xin-Yu Zhang, Lin Yang, Xiao-bin An, Yang Qu, Ya-ni Chai, Yan-Ru Wang, Ting-ting Li, Jing Ai
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
Chronic brain hypoperfusion
MicroRNA-195
Microglial/macrophage polarization
Neuronal-microglial cross-talk
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01919-w

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http://link.springer.com/article/10.1186/s12974-020-01919-w

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