Synthesis and Analgesic Effects of μ-TRTX-Hhn1b on Models of Inflammatory and Neuropathic Pain

Synthesis and Analgesic Effects of μ-TRTX-Hhn1b on Models of Inflammatory and Neuropathic Pain

μ-TRTX-Hhn1b (HNTX-IV) is a 35-amino acid peptide isolated from the venom of the spider, Ornithoctonus hainana. It inhibits voltage-gated sodium channel Nav1.7, which has been considered as a therapeutic target for pain. The goal of the present study is to elucidate the analgesic effects of syntheti...

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Bibliographic Details
Main Authors: Yu Liu, Jianguang Tang, Yunxiao Zhang, Xiaohong Xun, Dongfang Tang, Dezheng Peng, Jianming Yi, Zhonghua Liu, Xiaoliu Shi
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Toxins
Subjects:
μ-TRTX-Hhn1b
Nav1.7
analgesic
inflammatory pain
neuropathic pain
Online Access:http://www.mdpi.com/2072-6651/6/8/2363

Internet

http://www.mdpi.com/2072-6651/6/8/2363

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