Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome

Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome

Abstract Background Mutations in the cardiac sodium channel gene SCN5A cause Brugada syndrome (BrS), an arrhythmic disorder that is a leading cause of sudden death and lacks effective treatment. An association between SCN5A and Wnt/β-catenin signaling has been recently established. However, the role...

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Bibliographic Details
Main Authors: Dongsheng Cai, Xiaochen Wang, Yaxun Sun, Hangping Fan, Jingjun Zhou, Zongkuai Yang, Hangyuan Qiu, Jue Wang, Jun Su, Tingyu Gong, Chenyang Jiang, Ping Liang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Stem Cell Research & Therapy
Subjects:
iPSC-CMs
Brugada syndrome
SCN5A
Nav1.5
Wnt/β-catenin signaling
Online Access:https://doi.org/10.1186/s13287-023-03477-3

Internet

https://doi.org/10.1186/s13287-023-03477-3

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