Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

Histone ubiquitinations are critical for the activation of the DNA damage response (DDR). In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively. However, it remains to be defined how the ubiquitin pathway engages chromatin to...

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Bibliographic Details
Main Authors: Justin W Leung, Poonam Agarwal, Marella D Canny, Fade Gong, Aaron D Robison, Ilya J Finkelstein, Daniel Durocher, Kyle M Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3945288?pdf=render

Internet

http://europepmc.org/articles/PMC3945288?pdf=render

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