Identification of Epigenetically Modified Hub Genes and Altered Pathways Associated With Retinoblastoma

Identification of Epigenetically Modified Hub Genes and Altered Pathways Associated With Retinoblastoma

Retinoblastoma (Rb) is the most common childhood malignancy initiated by biallelic mutation in RB1 gene and driven by various epigenetic events including DNA methylation and microRNA dysregulation. Hence, understanding the key genes that are critically modulated by epigenetic modifications in RB1−/−...

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Bibliographic Details
Main Authors: Aditi Karmakar, Md. Maqsood Ahamad Khan, Nidhi Kumari, Nalini Devarajan, Senthil Kumar Ganesan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
retinoblastoma
epigenetics
DNA methylation
miRNAs
differentially expressed genes (DEGs)
hub genes
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.743224/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.743224/full

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