Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model

The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV)<b>.</b> Wild-type (WT) and <i>Sphk1</i> knockout (<i>Sphk1</i><sup>−<i>/</i>−...

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Bibliographic Details
Main Authors: Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
cornea
neovascularization
sphingolipid
sphingosine-1-phosphate
sphingosine kinase 1
Online Access:https://www.mdpi.com/2073-4409/11/18/2914

Internet

https://www.mdpi.com/2073-4409/11/18/2914

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