MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

RIG-I and MDA5 are cytosolic RNA sensors that play a critical role in innate antiviral responses. Major advances have been made in identifying RIG-I ligands, but our knowledge of the ligands for MDA5 remains restricted to data from transfection experiments mostly using poly(I:C), a synthetic dsRNA m...

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Bibliographic Details
Main Authors: Qian Feng, Stanleyson V. Hato, Martijn A. Langereis, Jan Zoll, Richard Virgen-Slane, Alys Peisley, Sun Hur, Bert L. Semler, Ronald P. van Rij, Frank J.M. van Kuppeveld
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712003415

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http://www.sciencedirect.com/science/article/pii/S2211124712003415

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