Cleavage-Mediated Regulation of Myd88 Signaling by Inflammasome-Activated Caspase-1

Cleavage-Mediated Regulation of Myd88 Signaling by Inflammasome-Activated Caspase-1

Coordination among multiple signaling pathways ensures an appropriate immune response, where a signaling pathway may impair or augment another signaling pathway. Here, we report a negative feedback regulation of signaling through the key innate immune mediator MyD88 by inflammasome-activated caspase...

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Bibliographic Details
Main Authors: Monika Avbelj, Iva Hafner-Bratkovič, Duško Lainšček, Mateja Manček-Keber, Tina Tinkara Peternelj, Gabriela Panter, Steven P. Treon, Boris Gole, Uroš Potočnik, Roman Jerala
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
Myd88
caspase-1
inflammasomes
regulation
innate immunity
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.790258/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.790258/full

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