| Summary: | A commonality between many cancers is that they have increased rates of glucose uptake that is, in turn, achieved by overexpression of cell
membrane localized uniporters called glucose transporters or GLUT. A 'near universal' approach to kill cancer cells lies in depriving them of their metabolic fuel, i.e. the preferential blockage of GLUT on malignant cells while
sparing GLUT on normal cells. As a first approximation, if glucose molecules could be conjugated to polyethylene glycol (PEG-Glu) at an end-to-end span distance lesser than the mean distance between two glucose transporters in normal cells, it could theoretically be possible to preferentially disable GLUT receptors on malignant cells on an equimolar excipient basis. This conceptual new molecule may potentially be deployed as an enabling excipient.
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