Polyethylene glycol glucose conjugate: an enabling excipient to block overexpressed glucose transporters on malignant cells
A commonality between many cancers is that they have increased rates of glucose uptake that is, in turn, achieved by overexpression of cell membrane localized uniporters called glucose transporters or GLUT. A 'near universal' approach to kill cancer cells lies in depriving them of their me...
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| Format: | Article |
| Language: | English |
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International Pharmaceutical Excipients Council
2016-09-01
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| Series: | Journal of Excipients and Food Chemicals |
| Online Access: | https://jefc.scholasticahq.com/article/922-polyethylene-glycol-glucose-conjugate-an-enabling-excipient-to-block-overexpressed-glucose-transporters-on-malignant-cells |
| _version_ | 1797254350251229184 |
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| author | Shireesh Apte |
| author_facet | Shireesh Apte |
| author_sort | Shireesh Apte |
| collection | DOAJ |
| description | A commonality between many cancers is that they have increased rates of glucose uptake that is, in turn, achieved by overexpression of cell
membrane localized uniporters called glucose transporters or GLUT. A 'near universal' approach to kill cancer cells lies in depriving them of their metabolic fuel, i.e. the preferential blockage of GLUT on malignant cells while
sparing GLUT on normal cells. As a first approximation, if glucose molecules could be conjugated to polyethylene glycol (PEG-Glu) at an end-to-end span distance lesser than the mean distance between two glucose transporters in normal cells, it could theoretically be possible to preferentially disable GLUT receptors on malignant cells on an equimolar excipient basis. This conceptual new molecule may potentially be deployed as an enabling excipient. |
| first_indexed | 2024-04-24T21:48:33Z |
| format | Article |
| id | doaj.art-07d3af89349a4db8aa1e55e413b220b0 |
| institution | Directory Open Access Journal |
| issn | 2150-2668 |
| language | English |
| last_indexed | 2024-04-24T21:48:33Z |
| publishDate | 2016-09-01 |
| publisher | International Pharmaceutical Excipients Council |
| record_format | Article |
| series | Journal of Excipients and Food Chemicals |
| spelling | doaj.art-07d3af89349a4db8aa1e55e413b220b02024-03-20T18:01:28ZengInternational Pharmaceutical Excipients CouncilJournal of Excipients and Food Chemicals2150-26682016-09-0164Polyethylene glycol glucose conjugate: an enabling excipient to block overexpressed glucose transporters on malignant cellsShireesh ApteA commonality between many cancers is that they have increased rates of glucose uptake that is, in turn, achieved by overexpression of cell membrane localized uniporters called glucose transporters or GLUT. A 'near universal' approach to kill cancer cells lies in depriving them of their metabolic fuel, i.e. the preferential blockage of GLUT on malignant cells while sparing GLUT on normal cells. As a first approximation, if glucose molecules could be conjugated to polyethylene glycol (PEG-Glu) at an end-to-end span distance lesser than the mean distance between two glucose transporters in normal cells, it could theoretically be possible to preferentially disable GLUT receptors on malignant cells on an equimolar excipient basis. This conceptual new molecule may potentially be deployed as an enabling excipient.https://jefc.scholasticahq.com/article/922-polyethylene-glycol-glucose-conjugate-an-enabling-excipient-to-block-overexpressed-glucose-transporters-on-malignant-cells |
| spellingShingle | Shireesh Apte Polyethylene glycol glucose conjugate: an enabling excipient to block overexpressed glucose transporters on malignant cells Journal of Excipients and Food Chemicals |
| title | Polyethylene glycol glucose conjugate: an enabling excipient to block overexpressed glucose transporters on malignant cells |
| title_full | Polyethylene glycol glucose conjugate: an enabling excipient to block overexpressed glucose transporters on malignant cells |
| title_fullStr | Polyethylene glycol glucose conjugate: an enabling excipient to block overexpressed glucose transporters on malignant cells |
| title_full_unstemmed | Polyethylene glycol glucose conjugate: an enabling excipient to block overexpressed glucose transporters on malignant cells |
| title_short | Polyethylene glycol glucose conjugate: an enabling excipient to block overexpressed glucose transporters on malignant cells |
| title_sort | polyethylene glycol glucose conjugate an enabling excipient to block overexpressed glucose transporters on malignant cells |
| url | https://jefc.scholasticahq.com/article/922-polyethylene-glycol-glucose-conjugate-an-enabling-excipient-to-block-overexpressed-glucose-transporters-on-malignant-cells |
| work_keys_str_mv | AT shireeshapte polyethyleneglycolglucoseconjugateanenablingexcipienttoblockoverexpressedglucosetransportersonmalignantcells |