The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Aβ clearance in 5XFAD miceResearch in context

The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Aβ clearance in 5XFAD miceResearch in context

Summary: Background: Previously, we showed that the sphingosine-1-phosphate (S1P) transporter spinster 2 (Spns2) mediates activation of microglia in response to amyloid β peptide (Aβ). Here, we investigated if Ponesimod, a functional S1P receptor 1 (S1PR1) antagonist, prevents Aβ-induced activation...

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Bibliographic Details
Main Authors: Zhihui Zhu, Liping Zhang, Ahmed Elsherbini, Simone M. Crivelli, Priyanka Tripathi, Carmen Harper, Zainuddin Quadri, Stefka D. Spassieva, Erhard Bieberich
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:EBioMedicine
Subjects:
Alzheimer's disease
Sphingosine-1-phosphate
Neuroinflammation
Ponesimod
Toll-like receptor 4
Phagocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423002785

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http://www.sciencedirect.com/science/article/pii/S2352396423002785

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