Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation

Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation

Abstract Finely tuned mitogen-activated protein kinase (MAPK) signaling is important for cancer cell survival. Perturbations that push cells out of the MAPK fitness zone result in cell death. Previously, in a screen of the North China Pharmaceutical Group Corporation’s pure compound library of micro...

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Bibliographic Details
Main Authors: Guan-Nan Li, Xue-Jiao Zhao, Zhen Wang, Meng-Shi Luo, Shen-Nan Shi, Dan-Mei Yan, Hua-Yi Li, Jia-Hao Liu, Yang Yang, Jia-Hong Tan, Ze-Yu Zhang, Ru-Qi Chen, Hui-Ling Lai, Xiao-Yuan Huang, Jian-Feng Zhou, Ding Ma, Yong Fang, Qing-Lei Gao
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-01131-7

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https://doi.org/10.1038/s41392-022-01131-7

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