Fyn kinase regulates dopaminergic neuronal apoptosis in animal and cell models of high glucose (HG) treatment

Fyn kinase regulates dopaminergic neuronal apoptosis in animal and cell models of high glucose (HG) treatment

Abstract Background High glucose (HG) is linked to dopaminergic neuron loss and related Parkinson’s disease (PD), but the mechanism is unclear. Results Rats and differentiated SH-SY5Y cells were used to investigate the effect of HG on dopaminergic neuronal apoptotic death. We found that a 40-day HG...

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Bibliographic Details
Main Authors: Changhong Tan, Xi Liu, Xiaoshuai Zhang, Wuxue Peng, Hui Wang, Wen Zhou, Jin Jiang, Lijuan Mo, Yangmei Chen, Lifen Chen
Format: Article
Language:English
Published: BMC 2021-12-01
Series:BMC Molecular and Cell Biology
Subjects:
High glucose
Dopaminergic neuronal apoptosis
Parkinson’s disease
Fyn
mTOR
Online Access:https://doi.org/10.1186/s12860-021-00398-y

Internet

https://doi.org/10.1186/s12860-021-00398-y

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