Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells

Abstract MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a human paracaspase protein with proteolytic activity via its caspase-like domain. The pharmacological inhibition of MALT1 by MI-2, a specific chemical inhibitor, diminishes the response of endothelial cells to in...

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Bibliographic Details
Main Authors: Binjie Yan, Darrell Belke, Yu Gui, Yong-Xiang Chen, Zhi-Sheng Jiang, Xi-Long Zheng
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01748-9