Developing BACE-1 inhibitors for FXS

Developing BACE-1 inhibitors for FXS

Fragile X syndrome (FXS) is a debilitating genetic disorder with no cure and few therapeutic options. Excessive signaling through metabotropic glutamate receptor 5 (mGluR5) in FXS leads to increased translation of numerous synaptic proteins and exaggerated long-term depression (LTD). Two of the over...

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Bibliographic Details
Main Authors: Cara J Westmark, Elizabeth M. Berry-Kravis, Chrysanthy eIkonomidou, Jerry eYin, Luigi ePuglielli
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer Disease
amyloid-beta
BACE-1
fragile X syndrome (FXS)
mGluR5
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00077/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00077/full

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