UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27

UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27

The UBE3A/E6-AP is known to function both as an E3 ubiquitin ligase of the ubiquitin proteasome system and as a transcriptional coactivator. E6-AP shows brain-specific imprinting and loss of function of maternally inherited E6-AP causes Angelman syndrome. However, how the loss of function of E6-AP c...

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Bibliographic Details
Main Authors: Amit Mishra, Swetha K. Godavarthi, Nihar Ranjan Jana
Format: Article
Language:English
Published: Elsevier 2009-10-01
Series:Neurobiology of Disease
Subjects:
E6-AP
UBE3A
Proteasome
p27
Angelman syndrome
Cell cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001594

Internet

http://www.sciencedirect.com/science/article/pii/S0969996109001594

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