Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis

Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis

Abstract Background The role of senescence in disease contexts is complex, however there is considerable evidence that depletion of senescent cells improves outcomes in a variety of contexts particularly related to aging, cognition, and neurodegeneration. Much research has shown previously that infl...

Full description

Bibliographic Details
Main Authors: Sienna S. Drake, Aliyah Zaman, Christine Gianfelice, Elizabeth M.-L. Hua, Kali Heale, Elia Afanasiev, Wendy Klement, Jo Anne Stratton, Alexandre Prat, Stephanie Zandee, Alyson E. Fournier
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Multiple sclerosis
Senescence
Neuroinflammation
Experimental autoimmune encephalomyelitis
Senolytics
Online Access:https://doi.org/10.1186/s12974-024-03278-2

Internet

https://doi.org/10.1186/s12974-024-03278-2

Similar Items