Regulating Chondrogenesis of Human Mesenchymal Stromal Cells with a Retinoic Acid Receptor-Beta Inhibitor: Differential Sensitivity of Chondral Versus Osteochondral Development

Regulating Chondrogenesis of Human Mesenchymal Stromal Cells with a Retinoic Acid Receptor-Beta Inhibitor: Differential Sensitivity of Chondral Versus Osteochondral Development

Aim: Main objective was to investigate whether the synthetic retinoic acid receptor (RAR)-β antagonist LE135 is able to drive in vitro chondrogenesis of human mesenchymal stromal cells (MSCs) or improve differentiation by suppressing hypertrophic chondrocyte development. Methods: Chondrogenesis of h...

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Bibliographic Details
Main Authors: Solvig Diederichs, Kerstin Zachert, Patric Raiss, Wiltrud Richter
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Human mesenchymal stromal cells
Chondrogenic differentiation
Endochondral differentiation
Retinole acid receptor antagonist
Online Access:http://www.karger.com/Article/FullText/358723

Internet

http://www.karger.com/Article/FullText/358723

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