Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in breast cancer among Indian population

Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in breast cancer among Indian population

Abstract Background Breast cancer (BC) is the most common malignancy with very high incidence and relatively high mortality in women. The PIK3CA gene plays a pivotal role in the pathogenicity of breast cancer. Despite this, the mutational status of all exons except exons 9 and 20 still remains unkno...

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Bibliographic Details
Main Authors: Rahul Kumar, Rakesh Kumar, Harsh Goel, Sonu Kumar, Somorjit Singh Ningombam, Imran Haider, Usha Agrawal, Svs Deo, Ajay Gogia, Atul Batra, Ashok Sharma, Sandeep Mathur, Amar Ranjan, Anita Chopra, Showket Hussain, Pranay Tanwar
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cancer Cell International
Subjects:
Breast cancer
Exome sequencing
PIK3CA
ddPCR
MD simulation
Online Access:https://doi.org/10.1186/s12935-023-03075-6

Internet

https://doi.org/10.1186/s12935-023-03075-6

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