Apolipoprotein A-II is catabolized in the kidney as a function of its plasma concentration

Apolipoprotein A-II is catabolized in the kidney as a function of its plasma concentration

We investigated in vivo catabolism of apolipoprotein A-II (apo A-II), a major determinant of plasma HDL levels. Like apoA-I, murine apoA-II (mapoA-II) and human apoA-II (hapoA-II) were reabsorbed in the first segment of kidney proximal tubules of control and hapoA-II-transgenic mice, respectively. A...

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Main Authors: Sonia Dugué-Pujol, Xavier Rousset, Danielle Château, Danièle Pastier, Christophe Klein, Jeannine Demeurie, Charlotte Cywiner-Golenzer, Michèle Chabert, Pierre Verroust, Jean Chambaz, François-Patrick Châtelet, Athina-Despina Kalopissis
Format: Article
Language:English
Published: Elsevier 2007-10-01
Series:Journal of Lipid Research
Subjects:
high density lipoprotein
cubilin
megalin
proximal tubule
yolk sac cells
mouse kidney cortical cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520424605

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http://www.sciencedirect.com/science/article/pii/S0022227520424605

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