Efficacy and Safety of a Modified Vaccinia Ankara-NP+M1 Vaccine Combined with QIV in People Aged 65 and Older: A Randomised Controlled Clinical Trial (INVICTUS)

Efficacy and Safety of a Modified Vaccinia Ankara-NP+M1 Vaccine Combined with QIV in People Aged 65 and Older: A Randomised Controlled Clinical Trial (INVICTUS)

Background: Pre-existing T cell responses to influenza have been correlated with improved clinical outcomes in natural history and human challenge studies. We aimed to determine the efficacy, safety and immunogenicity of a T-cell directed vaccine in older people. Methods: This was a multicentre, par...

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Bibliographic Details
Main Authors: Chris Butler, Chris Ellis, Pedro M. Folegatti, Hannah Swayze, Julie Allen, Louise Bussey, Duncan Bellamy, Alison Lawrie, Elizabeth Eagling-Vose, Ly-Mee Yu, Milensu Shanyinde, Catherine Mair, Amy Flaxman, Katie Ewer, Sarah Gilbert, Thomas G. Evans, on behalf of the INVICTUS Investigators
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Vaccines
Subjects:
MVA
influenza
vaccination
elderly
nucleoprotein
Online Access:https://www.mdpi.com/2076-393X/9/8/851

Internet

https://www.mdpi.com/2076-393X/9/8/851

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