Cardioprotective effects of early intervention with sacubitril/valsartan on pressure overloaded rat hearts

Abstract Left ventricular remodeling due to pressure overload is associated with poor prognosis. Sacubitril/valsartan is the first-in-class Angiotensin Receptor Neprilysin Inhibitor and has been demonstrated to have superior beneficial effects in the settings of heart failure. The aim of this study...

Full description

Bibliographic Details
Main Authors: Xiaofei Li, Julie Braza, Ulrike Mende, Gaurav Choudhary, Peng Zhang
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-95988-3