Fractalkine/CX3CL1 engages different neuroprotective responses upon selective glutamate receptor overactivation.

Fractalkine/CX3CL1 engages different neuroprotective responses upon selective glutamate receptor overactivation.

Neuronal death induced by overactivation of N-methyl-d-aspartate receptors (NMDARs) is implicated in the pathophysiology of many neurodegenerative diseases such as stroke, epilepsy and traumatic brain injury. This toxic effect is mainly mediated by NR2B-containing extrasynaptic NMDARs, while NR2A-co...

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Bibliographic Details
Main Authors: Clotilde eLauro, Myriam eCatalano, Eleonora eDi Paolo, Giuseppina eChece, Ida ede Costanzo, Flavia eTrettel, Cristina eLimatola
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neuroprotection
NMDA
d-serine
excitotoxicity
CX3CL1
A2AR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00472/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00472/full

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