Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages

Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages

Hepatocyte growth factor, produced by stromal and follicular dendritic cells, and present at high concentrations in the sera of patients with chronic lymphocytic leukemia, prolongs the survival of leukemic B cells by interacting with their receptor, c-MET. It is, however, unknown whether hepatocyte...

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Bibliographic Details
Main Authors: Paolo Giannoni, Gabriella Pietra, Giorgia Travaini, Rodolfo Quarto, Genti Shyti, Roberto Benelli, Laura Ottaggio, Maria Cristina Mingari, Simona Zupo, Giovanna Cutrona, Ivana Pierri, Enrico Balleari, Alessandra Pattarozzi, Marco Calvaruso, Claudio Tripodo, Manlio Ferrarini, Daniela de Totero
Format: Article
Language:English
Published: Ferrata Storti Foundation 2014-06-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/7049

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https://haematologica.org/article/view/7049

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