In situ antibody phage display yields optimal inhibitors of integrin α11/β1

In situ antibody phage display yields optimal inhibitors of integrin α11/β1

Integrins are transmembrane multi-conformation receptors that mediate interactions with the extracellular matrix. In cancer, integrins influence metastasis, proliferation, and survival. Collagen-binding integrin-α11/β1, a marker of aggressive tumors that is involved in stroma-tumor crosstalk, may be...

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Bibliographic Details
Main Authors: Eugenio Gallo, Abdellali Kelil, Peter E. Bayliss, Ajitha Jeganathan, Olga Egorova, Lynda Ploder, Jarrett J. Adams, Patricia Giblin, Sachdev S. Sidhu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Enhanced diversity
antibody selections
cellular selections
ITGA11
integrin-α11/β1 receptor
cancer therapeutics
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1717265

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2020.1717265

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