Susceptibility of primary human airway epithelial cells to adenylate cyclase toxin in two- and three-dimensional culture conditions

The human pathogen Bordetella pertussis targets the respiratory epithelium and causes whooping cough. Its virulence factor adenylate cyclase toxin (CyaA) plays an important role in the course of infection. Previous studies on the impact of CyaA on human epithelial cells have been carried out using c...

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Bibliographic Details
Main Authors: Maria Bianchi, Rinu Sivarajan, Thorsten Walles, Stephan Hackenberg, Maria Steinke
Format: Article
Language:English
Published: SAGE Publishing 2021-01-01
Series:Innate Immunity
Online Access:https://doi.org/10.1177/1753425920979354