Revolutionizing cancer treatment: enhancing CAR-T cell therapy with CRISPR/Cas9 gene editing technology

Revolutionizing cancer treatment: enhancing CAR-T cell therapy with CRISPR/Cas9 gene editing technology

CAR-T cell therapy, a novel immunotherapy, has made significant breakthroughs in clinical practice, particularly in treating B-cell-associated leukemia and lymphoma. However, it still faces challenges such as poor persistence, limited proliferation capacity, high manufacturing costs, and suboptimal...

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Bibliographic Details
Main Authors: Ruiyu Tao, Xiaopeng Han, Xue Bai, Jianping Yu, Youwei Ma, Weikai Chen, Dawei Zhang, Zhengkai Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
CAR-T cell
CRISPR/Cas9
immune checkpoints
durability
cost
security
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354825/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354825/full

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