Sp1 facilitates continued HSV-1 gene expression in the absence of key viral transactivators

Sp1 facilitates continued HSV-1 gene expression in the absence of key viral transactivators

ABSTRACTProductive replication of herpes simplex virus (HSV) relies upon a well-ordered transcriptional cascade flowing from immediate-early (IE) to early (E) to late (L) gene products. While several virus-encoded transcriptional activators are involved in this process, IE and E gene promoters also...

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Bibliographic Details
Main Authors: Catherine N. Sodroski, Hyung Suk Oh, Shu-Fan Chou, David M. Knipe
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
herpes simplex virus
transcription factor
interferon
transactivator
ICP0
Sp1
Online Access:https://journals.asm.org/doi/10.1128/mbio.03479-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03479-23

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