CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma

CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma

BRAF is a serine/threonine kinase that harbors activating mutations in ∼7% of human malignancies and ∼60% of melanomas. Despite initial clinical responses to BRAF inhibitors, patients frequently develop drug resistance. To identify candidate therapeutic targets for BRAF inhibitor resistant melanoma,...

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Bibliographic Details
Main Authors: Ziyi Li, Binbin Wang, Shengqing Gu, Peng Jiang, Avinash Sahu, Chen-Hao Chen, Tong Han, Sailing Shi, Xiaoqing Wang, Nicole Traugh, Hailing Liu, Yin Liu, Qiu Wu, Myles Brown, Tengfei Xiao, Genevieve M. Boland, X. Shirley Liu
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Drug resistance
CRISPR screen
Melanoma
BRAF inhibitor
Gene regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022920300528

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http://www.sciencedirect.com/science/article/pii/S1672022920300528

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