Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages

Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages

Lipin2 is a phosphatidate phosphatase that plays critical roles in fat homeostasis. Alterations in <i>Lpin2</i>, which encodes lipin2, cause the autoinflammatory bone disorder Majeed syndrome. Lipin2 limits lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. However,...

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Bibliographic Details
Main Authors: Asami Watahiki, Seira Hoshikawa, Mitsuki Chiba, Hiroshi Egusa, Satoshi Fukumoto, Hiroyuki Inuzuka
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
lipin2
Majeed syndrome
macrophage
autoinflammatory bone disorder
inflammation
osteoclastogenesis
Online Access:https://www.mdpi.com/1422-0067/22/6/2893

Internet

https://www.mdpi.com/1422-0067/22/6/2893

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