Inhibition of protein translation under matrix-deprivation stress in breast cancer cells

Inhibition of protein translation under matrix-deprivation stress in breast cancer cells

Matrix-deprivation stress leads to cell-death by anoikis, whereas overcoming anoikis is critical for cancer metastasis. Work from our lab and others has identified a crucial role for the cellular energy sensor AMPK in anoikis-resistance, highlighting a key role for metabolic reprogramming in stress...

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Bibliographic Details
Main Authors: Shweta Warrier, Shivaani Srinivasan, Adithya Chedere, Annapoorni Rangarajan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Medicine
Subjects:
protein translation
stress
matrix-deprivation
translatome
mTORC1
ISR
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1124514/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1124514/full

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