Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer

Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer

Epigenetic therapies that cause genome-wide epigenetic alterations, could trigger local interplay between different histone marks, leading to a switch of transcriptional outcome and therapeutic responses of epigenetic treatment. However, in human cancers with diverse oncogenic activation, how oncoge...

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Bibliographic Details
Main Authors: Xiaomin Wang, Jun Xu, Yiming Sun, Siyuwei Cao, Hanlin Zeng, Nan Jin, Matthew Shou, Shuai Tang, Yi Chen, Min Huang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
HDAC inhibitors
Drug resistance
Histone methylation
Histone acetylation
Epigenetic interplay
Hedgehog pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523000989

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http://www.sciencedirect.com/science/article/pii/S2211383523000989

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