Molecular Mechanisms of Leukocyte Migration and Its Potential Targeting—Lessons Learned From MKL1/SRF-Related Primary Immunodeficiency Diseases

Molecular Mechanisms of Leukocyte Migration and Its Potential Targeting—Lessons Learned From MKL1/SRF-Related Primary Immunodeficiency Diseases

Megakaryoblastic leukemia 1 (MKL1) deficiency is one of the most recently discovered primary immunodeficiencies (PIDs) caused by cytoskeletal abnormalities. These immunological “actinopathies” primarily affect hematopoietic cells, resulting in defects in both the innate immune system (phagocyte defe...

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Bibliographic Details
Main Authors: Evelien G. G. Sprenkeler, Carla Guenther, Imrul Faisal, Taco W. Kuijpers, Susanna C. Fagerholm
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
MKL1
SRF
neutrophil
migration
immunodeficiency—primary
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.615477/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.615477/full

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