Unbiased Characterization of Peptide-HLA Class II Interactions Based on Large-Scale Peptide Microarrays; Assessment of the Impact on HLA Class II Ligand and Epitope Prediction

Unbiased Characterization of Peptide-HLA Class II Interactions Based on Large-Scale Peptide Microarrays; Assessment of the Impact on HLA Class II Ligand and Epitope Prediction

Human Leukocyte Antigen class II (HLA-II) molecules present peptides to T lymphocytes and play an important role in adaptive immune responses. Characterizing the binding specificity of single HLA-II molecules has profound impacts for understanding cellular immunity, identifying the cause of autoimmu...

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Bibliographic Details
Main Authors: Mareike Wendorff, Heli M. Garcia Alvarez, Thomas Østerbye, Hesham ElAbd, Elisa Rosati, Frauke Degenhardt, Søren Buus, Andre Franke, Morten Nielsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
ultra-high density peptide microarray
MHC class II
HLA
antigen presentation
prediction
peptide binding
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01705/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01705/full

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