In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research. Here, we fully characterized iPSC-derived beta cell function in vitro and in vivo in humanized mice. Using a 7-stage protocol, human iPSCs were differen...

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Bibliographic Details
Main Authors: Federica Fantuzzi, Sanna Toivonen, Andrea Alex Schiavo, Heeyoung Chae, Mohammad Tariq, Toshiaki Sawatani, Nathalie Pachera, Ying Cai, Chiara Vinci, Enrico Virgilio, Laurence Ladriere, Mara Suleiman, Piero Marchetti, Jean-Christophe Jonas, Patrick Gilon, Décio L. Eizirik, Mariana Igoillo-Esteve, Miriam Cnop
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
aggregate, beta cell
human induced pluripotent stem cell
insulin secretion
islet
microwell
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.967765/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.967765/full

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