An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy.

An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy.

Rift Valley fever virus (RVFV) is a viral zoonosis that causes severe disease in ruminants and humans. The nonstructural small (NSs) protein is the primary virulence factor of RVFV that suppresses the host's antiviral innate immune response. Bioinformatic analysis and AlphaFold structural model...

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Bibliographic Details
Main Authors: Kaylee Petraccione, Mohamed G H Ali, Normand Cyr, Haytham M Wahba, Timothy Stocker, Maryna Akhrymuk, Ivan Akhrymuk, Lauren Panny, Nicole Bracci, Raphaël Cafaro, Danuta Sastre, Andrew Silberfarb, Paul O'Maille, James Omichinski, Kylene Kehn-Hall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012093

Internet

https://doi.org/10.1371/journal.ppat.1012093

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