Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of <i>Bordetella pertussis</i>

Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of <i>Bordetella pertussis</i>

The whooping cough agent, <i>Bordetella pertussis</i>, secretes an adenylate cyclase toxin–hemolysin (CyaA, ACT, or AC-Hly) that catalyzes the conversion of intracellular ATP to cAMP and through its signaling annihilates the bactericidal activities of host sentinel phagocytes. In paralle...

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Bibliographic Details
Main Authors: Jana Holubova, Attila Juhasz, Jiri Masin, Ondrej Stanek, David Jurnecka, Adriana Osickova, Peter Sebo, Radim Osicka
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
adenylate cyclase toxin
<i>Bordetella pertussis</i>
cAMP intoxication
lung colonization
lung inflammation
pore-forming activity
Online Access:https://www.mdpi.com/1422-0067/22/21/11655

Internet

https://www.mdpi.com/1422-0067/22/21/11655

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