Scaling up for the industrial production of rifamycin B; optimization of the process conditions in bench-scale fermentor

Scaling up for the industrial production of rifamycin B; optimization of the process conditions in bench-scale fermentor

Optimization of fermentation process conditions using a gene amplified variant of Amycolatopsis mediterranei (NCH) was carried out. The use of aeration level 1.5 vvm increased the yield by 16.6% (from 13.81 to 16.1 g/l) upon controlling the temperature at 28 °C. Adjustment of the aeration level at 1...

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Bibliographic Details
Main Authors: Hewaida F. El-Sedawy, Manal M.M. Hussein, Tamer Essam, Ossama M. El-Tayeb, Fatma H.A. Mohammad
Format: Article
Language:English
Published: Faculty of Pharmacy, Cairo University 2013-06-01
Series:Bulletin of Faculty of Pharmacy Cairo University
Subjects:
Amycolatopsis mediterranei
Antibiotics
Fermentor
Rifamycin B
Scaling up
Online Access:http://www.sciencedirect.com/science/article/pii/S1110093113000045

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http://www.sciencedirect.com/science/article/pii/S1110093113000045

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