Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits

Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits

The transforming growth factor-betas (TGF-βs) regulate the induction of dopaminergic neurons and are elevated in the CSF of Parkinson's patients. We report here that mice with TGF-β2 haploinsufficiency (TGF-β2+/−) have subclinical defects in the dopaminergic neurons of their substantia nigra pa...

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Bibliographic Details
Main Authors: Zane B. Andrews, Hua Zhao, Tony Frugier, Reiko Meguro, David R. Grattan, Kyoko Koishi, Ian S. McLennan
Format: Article
Language:English
Published: Elsevier 2006-03-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Dopamine
DOPAC
TGF-β2
Substantia nigra
Susceptibility genes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002457

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http://www.sciencedirect.com/science/article/pii/S0969996105002457

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