BACH1 controls hepatic insulin signaling and glucose homeostasis in mice

Abstract Hepatic insulin resistance is central to the metabolic syndrome. Here we investigate the role of BTB and CNC homology 1 (BACH1) in hepatic insulin signaling. BACH1 is elevated in the hepatocytes of individuals with obesity and patients with non-alcoholic fatty liver disease (NAFLD). Hepatoc...

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Bibliographic Details
Main Authors: Jiayu Jin, Yunquan He, Jieyu Guo, Qi Pan, Xiangxiang Wei, Chen Xu, Zhiyuan Qi, Qinhan Li, Siyu Ma, Jiayi Lin, Nan Jiang, Jinghua Ma, Xinhong Wang, Lindi Jiang, Qiurong Ding, Elena Osto, Xiuling Zhi, Dan Meng
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44088-z