Parainfluenza Virus 5 Priming Followed by SIV/HIV Virus-Like-Particle Boosting Induces Potent and Durable Immune Responses in Nonhuman Primates

Parainfluenza Virus 5 Priming Followed by SIV/HIV Virus-Like-Particle Boosting Induces Potent and Durable Immune Responses in Nonhuman Primates

The search for a preventive vaccine against HIV infection remains an ongoing challenge, indicating the need for novel approaches. Parainfluenza virus 5 (PIV5) is a paramyxovirus replicating in the upper airways that is not associated with any animal or human pathology. In animal models, PIV5-vectore...

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Bibliographic Details
Main Authors: Peng Xiao, Krista Dienger-Stambaugh, Xuemin Chen, Huiling Wei, Shannon Phan, Ashley C. Beavis, Karnail Singh, Nihar R. Deb Adhikary, Pooja Tiwari, Francois Villinger, Biao He, Paul Spearman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
parainfluenza virus 5 (PIV5)
human immunodeficiency virus (HIV) vaccine
virus-like particles (VLP)
rhesus macaques
immune responses
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.623996/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.623996/full

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